Invasive species across taxa have had substantial ecological effects in the Great Lakes region. This region encompasses a large geographic area, and is particularly vulnerable to invasive species transport due to its interconnected waterways and role in the international shipping industry. The Center has a long history of conducting research on invasive Great Lakes species, beginning with investigations of rainbow smelt population biology in the 1930s. Perhaps the best known example of Center work on invasive species has been its long standing research program involving the sea lamprey. To understand ecosystem impacts of invasive species, current approaches integrate observational, experimental, and modeling methods to characterize the biotic and abiotic drivers of invasion. The Center’s research program will provide a systems perspective to promote Great Lakes ecosystems where invasive species or their negative impacts are prevented, managed or eradicated. Center researchers will produce scientifically grounded, innovative, and proactive and interdisciplinary research in support of this vision.